Deploy repurposed small-molecule toxin inhibitors as broad-spectrum early therapy
#00134
Use varespladib (PLA2 inhibitor), marimastat (SVMP inhibitor), and DMPS/dimercaprol (Zn2+ chelators) as cheap, heat-stable, species-agnostic first-line treatment that buys time before or alongside antivenom, particularly in the pre-hospital window.
Ophirex, Inc. (sponsor), with emergency-department sites in India and the USA · 2021–2022 · National
BRAVO was a double-blind, randomised, placebo-controlled phase II trial of oral varespladib-methyl plus standard care (including antivenom) versus standard care plus placebo, run in emergency departments in India (Puduc…
Patients randomised95patients
Snakebite Severity Score improvement vs placebo (overall)difference −0.4 (95% CI −0.8 to 0.1) → not significant (p=0.13)
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