Replace animal-derived antivenom with broadly-neutralizing recombinant human antibody cocktails
#00131
Manufacture antivenom as a defined cocktail of recombinant human monoclonal antibodies targeting conserved toxin families (3FTx, PLA2, SVMP, SVSP), replacing dozens of narrow regional polyclonal sera with a small number of broad-spectrum products split roughly by neurotoxic-elapi
Centivax, Inc.; Columbia University; NIAID (US National Institute of Allergy and Infectious Diseases) · Global
Researchers isolated broadly-neutralizing IgG antibodies from the memory B-cells of a human donor (Tim Friede) who had self-immunized with escalating venom doses from 16 lethal elapid species over ~18 years. Two antibod…
Elapid species with full protection (mouse model)13 of 19
Elapid species with partial protection (mouse model)6 of 19
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