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Case study of

#00135 Use antivenomics to map and license cross-neutralization of existing products against orphan species

Liverpool School of Tropical Medicine, UK (venoms sourced from 13 sub-Saharan African countries)

#00134

OngoingRegion

Implementer

Liverpool School of Tropical Medicine (Centre for Snakebite Research & Interventions) and collaborators

Location

Liverpool School of Tropical Medicine, UK (venoms sourced from 13 sub-Saharan African countries)53.4087, -2.9695

Description

Rather than develop a new product, researchers tested whether an existing polyvalent antivenom (PANAF-Premium, Premium Serums & Vaccines) already neutralizes the venoms of medically important sub-Saharan African snakes for which no specific antivenom is marketed. Using preclinical neutralization assays (murine model), they assessed its potency against venoms from 14 'orphan' species drawn from 13 countries. The study demonstrated broad paraspecific coverage, mapping latent capacity that could be deployed via label extension and procurement — pending clinical confirmation.

Metrics

2
Orphan species (no specific product) assessed14species
Sub-Saharan African countries covered13countries

Lessons learned

  • Effective coverage for many 'orphan' species already exists unused inside current polyvalent products; systematically measuring it is high-leverage and cheap relative to new product development.
  • Preclinical neutralization is necessary but not sufficient — clinical validation and regulatory label extension are the gating steps before cross-neutralization mapping changes practice.

Documented Jul 8, 2026

Author AvatarArnaud Gissinger

History

· 1
Createdapproved

Arnaud Gissinger · 1h ago · approved by Arnaud Gissinger 1h ago


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